Xerese has been proven to speed up healing and reduce the tenderness of an outbreak.

Clinical proof

In a clinical study, 42% of patients who applied XERESE within an hour of the first signs or symptoms prevented their cold sores from progressing to the ulcerative stage (when they burst and form painful sores).*

Additionally, XERESE:

Reduced average cold sore size by 50% compared to placebo

In another clinical study, XERESE:

Reduced healing time by 1.6 days
Reduced symptoms such as tenderness

*Randomized study of 1,443 treated patients; 601 received XERESE.

†Randomized study of 380 adults of whom 120 developed lesions; 50 were treated with XERESE and 70 received placebo.

Talk to your healthcare provider if your cold sore is not better in 2 weeks.

XERESE® (acyclovir and hydrocortisone) cream 5%/1% is a prescription medicine used in patients ages 6 and older to lessen the healing time of cold sores (herpes labialis) and lessen the chance of a cold sore becoming worse (ulcerating). It should be used early, at the first sign of a cold sore.
 

Important Safety Information


INDICATION

XERESE® (acyclovir and hydrocortisone) cream 5%/1% is a prescription medicine used in patients ages 6 and older to lessen the healing time of cold sores (herpes labialis) and lessen the chance of a cold sore becoming worse (ulcerating). It should be used early, at the first sign of a cold sore.

Important safety information
  • XERESE is for cold sores on lips and around the mouth only and should not be used in eyes, mouth, nose or on genitals. Use exactly as directed by your healthcare provider.
  • XERESE is not a cure for cold sores.
  • It is not known if XERESE is safe for or works in children younger than 6 years old.
  • The safety of XERESE is unknown in women who are pregnant or breast-feeding, or in patients with a weak immune system (become sick very easily). Tell your healthcare provider about these or any other medical conditions you have before using XERESE.
  • Do not cover the cold sore or the area around the cold sore with a bandage.
  • Do not use other skin products (such as make-up, sun screen or lip balm) or other skin medicine on the cold sore or the area around the cold sore.
  • Talk to your healthcare provider if your cold sore is not better in 2 weeks.
  • The most common side effects of XERESE are: drying or flaking of the skin, tingling or burning after applying it, redness of the skin and swelling or changes in skin color where the cream is applied. These are not all the possible side effects of XERESE. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Click here for full Prescribing Information.