There are many treatment options - It's important to talk to a doctor.

Treatment options

There is no cure for cold sores. Cold sores are caused by the HSV-1 virus, which stays in your body throughout your lifetime. This may sound disheartening—but try not to let it discourage you. Know that your symptoms will come and go, and often, you won’t have any at all. Also know that there are many treatments available to help you manage cold sores.

Over-the-counter treatments

OTC means "over-the-counter," so you can buy them without a prescription. OTC can include topical medications such as gels, creams or ointments. While OTCs may help some people, others may need a prescription-strength treatment.

Oral vs topical treatments

There are two kinds of prescription treatments for cold sores, oral and topical medicines. Prescription antivirals are taken orally as a pill, while topical medicines, such as gels, creams, or ointments, are applied to the cold sore itself.

Oral and topical medications may have different side effects. Always talk to your doctor about your treatment options. It's important to be an active part of your care to find the treatment that's right for you for managing your cold sores.

What makes XERESE different?

  • XERESE is the first and only cold sore medication that combines an antiviral drug (acyclovir) and an
    anti-inflammatory drug (hydrocortisone) in one
    easy-to-apply cream.
  • Acyclovir helps block the cold sore virus from replicating, or copying itself.
  • Hydrocortisone is a treatment to help reduce inflammation.

It’s important to remember that XERESE is not a cure—there is no cure for cold sores. But, it can help treat the symptoms, reduce severity, and speed healing time in some patients. See Important Safety Information below.

XERESE® (acyclovir and hydrocortisone) cream 5%/1% is a prescription medicine used in patients ages 6 and older to lessen the healing time of cold sores (herpes labialis) and lessen the chance of a cold sore becoming worse (ulcerating). It should be used early, at the first sign of a cold sore.
 

Important Safety Information

INDICATION

XERESE® (acyclovir and hydrocortisone) cream 5%/1% is a prescription medicine used in patients ages 6 and older to lessen the healing time of cold sores (herpes labialis) and lessen the chance of a cold sore becoming worse (ulcerating). It should be used early, at the first sign of a cold sore.

Important safety information
  • XERESE is for cold sores on lips and around the mouth only and should not be used in eyes, mouth, nose or on genitals. Use exactly as directed by your healthcare provider.
  • XERESE is not a cure for cold sores.
  • It is not known if XERESE is safe for or works in children younger than 6 years old.
  • The safety of XERESE is unknown in women who are pregnant or breast-feeding, or in patients with a weak immune system (become sick very easily). Tell your healthcare provider about these or any other medical conditions you have before using XERESE.
  • Do not cover the cold sore or the area around the cold sore with a bandage.
  • Do not use other skin products (such as make-up, sun screen or lip balm) or other skin medicine on the cold sore or the area around the cold sore.
  • Talk to your healthcare provider if your cold sore is not better in 2 weeks.
  • The most common side effects of XERESE are: drying or flaking of the skin, tingling or burning after applying it, redness of the skin and swelling or changes in skin color where the cream is applied. These are not all the possible side effects of XERESE. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Click here for full Prescribing Information.