For patients with recurrent herpes labialis (cold sores) choose xerese.

  • The Xerese Dual Action Effect
  • Treat the virus and reduce the inflammation
  • Dosing and Administration
Approaches to Topical Management of Herpes Labialis: Watch Now
Instant Savings Offer

1. XERESE® (acyclovir and hydrocortisone) cream 5%/1% Prescribing Information. January, 2014.


XERESE® HC (acyclovir and hydrocortisone) Cream 5% /1% is indicated for the early treatment of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time in patients 6 years of age and older.

Important safety information

XERESE (acyclovir and hydrocortisone) Cream 5% /1% is intended for cutaneous use only, on the lips and around the mouth. XERESE should not be used in the eye, inside the mouth or nose, or on the genitals.

Systemic exposure to acyclovir and hydrocortisone following topical administration is minimal. Caution should be exercised when XERESE is administered to women who are pregnant or nursing. The benefit of XERESE has not been adequately assessed in immunocompromised patients.

XERESE has a potential for irritation and contact sensitization.

In clinical trials, the most common adverse reactions in the area of the application site included drying or flaking of the skin; burning or tingling following application; erythema; pigmentation changes; application site reaction including signs and symptoms of inflammation. Each event occurred in less than 1% of patients.

Patients should be encouraged to seek medical advice when a cold sore fails to heal within 2 weeks.

*This offer is only valid for patients with commercial insurance. Eligible uninsured patients will pay more. This offer is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. This offer is good only in the U.S. at retail pharmacies owned and operated by Walgreen Co. (or its affiliates) or other participating independent retail pharmacies. This offer is not valid in Massachusetts or Minnesota or where otherwise prohibited, taxed or otherwise restricted. Click here for other terms and conditions that apply.